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Lucilia sericata Chymotrypsin Disrupts Protein Adhesin-Mediated Staphylococcal Biofilm Formation |
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| Authors: | Llinos G Harris Yamni Nigam James Sawyer Dietrich Mack David I Pritchard |
| Institution: | aMedical Microbiology and Infectious Diseases, Institute of Life Science, College of Medicine, Swansea University, Swansea, United Kingdom;bCentre for Long Term and Chronic Conditions, College of Human and Health Sciences, Swansea University, Swansea, United Kingdom;cImmune Modulation Research Group, School of Pharmacy, University of Nottingham, Nottingham, United Kingdom |
| Abstract: | Staphylococcus aureus and Staphylococcus epidermidis biofilms cause chronic infections due to their ability to form biofilms. The excretions/secretions of Lucilia sericata larvae (maggots) have effective activity for debridement and disruption of bacterial biofilms. In this paper, we demonstrate how chymotrypsin derived from maggot excretions/secretions disrupts protein-dependent bacterial biofilm formation mechanisms. |
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