Protection of DAergic neurons mediates treadmill running attenuated olfactory deficits and olfactory neurogenesis promotion in depression model |
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| Institution: | 1. School of Physical Exercise, Taiyuan University of Technology, Taiyuan, China;2. Shanxi Finance & Tax College, Taiyuan, China;1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Department of Pharmacology, Xuzhou Medical University, Xuzhou 221004, China;2. Department of Pharmacy, The First People''s Hospital of Wujiang, Suzhou 215200, China;3. Department of Pharmacy, The People''s Hospital of Jiangyin, Wuxi 214400, China;1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Department of Pharmacology, Xuzhou Medical College, Xuzhou 221004, China;2. Department of Pharmacy, The People''s Hospital of Xinyi, Xuzhou 221004, China;1. Department of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China;2. Research Institute of Otolaryngology-Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, China;1. Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, 226001, Jiangsu, China;2. Provincial Key Laboratory of Inflammation and Molecular Drug Target, Jiangsu, China |
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| Abstract: | In this study, we aimed to test the effects of treadmill running on depression induced olfactory functions and OB neurogenesis in depression model. Depression model was created with chronic unpredictable mild stress (CUMS) and treadmill running was performed as the antidepressant treatment. Behavioral results showed that treadmill running not only attenuated the depression mood but also improved the olfactory discrimination and sensitivity in CUMS depression model. Immune-staining further indicates treadmill running promoted neurogenesis in hippocampal OB region. Moreover, treadmill running prevented the loss of DAergic neurons in glomerular layer of OB region, indicating the critical role of DAergic neuronal functions in regulating treadmill running mediated olfactory functions. In depression model, inhibiting DAergic neurons by intra-OB injection of 6-OHDA resulted in the compromised improving effects of treadmill running olfactory discrimination. In conclusion, treadmill running could attenuate depression associated olfactory deficits by promoting olfactory neurogenesis and improve DAergic neural functions. |
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| Keywords: | Depression Treadmill running Olfactory bulbs Neurogenesis Dopaminergic neurons |
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