Effect of prostaglandins A1, A2, B1, B2, E2 and F2α on human umbilical cord vessels |
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Authors: | Ganesan P. Adaikan S. M. M. Karim |
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Abstract: | The effect of six naturally occurring prostaglandins on isolated umbilical arteries and veins has been studied. All six prostaglandins had a constricting effect on the umbilical vessels. On the umbilical artery preparations the potencies in decreasing order were A2>B2>F2α>B1>E2>A1. Prostaglandin B2 was more potent than PGA2 on the umbilical vein. Polyphloretin phosphate (PPP) antagonised the constricting effect of all six prostaglandins without altering responses to 5-hydroxytryptamine. |
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