Image contrast agents activated by prostate specific antigen (PSA) |
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| Authors: | Jones Graham B Xie Longfei El-Shafey Ahmed Crasto Curtis F Bubley Glenn J D'Amico Anthony V |
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| Affiliation: | Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, USA. gr.jones@neu.edu |
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| Abstract: | A family of image contrast agent conjugates designed to undergo enzymatic activation has been synthesized. The agents underwent activation both with enzymatically active prostate specific antigen and alpha-chymotrypsin, releasing free fluorophore via cleavage of a three-component system. |
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