Structure of the type 5 capsular polysaccharide of Staphylococcus aureus |
| |
| Authors: | M Moreau J C Richards J M Fournier R A Byrd W W Karakawa W F Vann |
| |
| Institution: | Office of Biologics Research and Review, Food and Drug Administration, Bethesda, Maryland 20892. |
| |
| Abstract: | The Staphylococcus aureus type 5 capsular polysaccharide is composed of 2-acetamido-2-deoxy-L-fucose (1 part), 2-acetamido-2-deoxy-D-fucose (1 part), and 2-acetamido-2-deoxy-D-mannuronic acid (1 part). On the basis of methylation analysis, optical rotation, high-field one- and two-dimensional 1H- and 13C-n.m.r. experiments, and selective cleavage with 70% aqueous hydrogen fluoride, the polysaccharide was found to be a partially O-acetylated (50%) polymer of the repeating trisaccharide unit, ----4)-3-O-Ac-beta-D-ManpNAcA-(1----4)-a-L-FucpNAc-(1----3) -beta-D-FucpNAc-(1----]n. |
| |
| Keywords: | |
|
|
