Isolation of mutagenic beta-carboline derivatives after nitrite treatment of maillard reaction mixtures and analysis of these compounds from foodstuffs and human urine |
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Authors: | Masuda Shuichi Kanamori Hisayuki Kinae Naohide |
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Affiliation: | Department of Food and Nutritional Sciences, Graduate School of Nutritional and Environmental Sciences and COE Program in the 21st Century, University of Shizuoka, Japan. masudas@u-shizuoka-ken.ac.jp |
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Abstract: | Mixtures of carbohydrate decomposition products and L-tryptophan were incubated at pH 7.0 and 37 degrees C for 4 weeks. These mixtures exhibited mutagenic activity toward S. typhimurium TA 100 without metabolic activation after a nitrite treatment at pH 4.0. Four beta-carboline derivatives were isolated as premutagens from mixtures of methylglyoxal and furfural. These premutagens were also found to be contained in daily foodstuffs and human urine samples. |
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