Appearance of hCG-receptor after conversion of newborn ovarian cells into testicular structures by H-Y antigen in vitro |
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Authors: | U. Müller Maria Teresa Zenzes T. Bauknecht U. Wolf J. W. Siebers W. Engel |
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Affiliation: | (1) Institut für Humangenetik and Anthropologie der Universität Freiburg I. Br., Federal Republic of Germany;(2) Universitäts-Frauenklinik Freiburg i. Br., Federal Republic of Germany;(3) Institut für Humangenetik der Universität Göttingen, Federal Republic of Germany |
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Abstract: | Summary In a previous report (Zenzes et al., 1978 b) it was shown that dissociated ovarian cells of newborn rats in vitro, if exposed to H-Y antigen, reorganize into testicular structures. The current study was designed to see whether this morphological conversion also results in a functional conversion. The LH/hCG receptor was used as a parameter characteristic for the newborn testis, but not for the newborn ovary. In the converted ovary, the LH/hCG receptor becomes detectable a few hours after onset of the culture and remains continuously present afterward. The appearance of this receptor may be due to a hormone-like action of H-Y antigen. |
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