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Lambda's switch: lessons from a module swap |
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| Authors: | Ptashne Mark |
| Affiliation: | Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA. m-ptashne@mskcc.org |
| Abstract: | A recent experiment has replaced Cro, a crucial component of lambda's genetic switch, with the lac repressor (plus two lac operators). The resulting hybrid phage is viable, but a subtle phenotypic defect explains a puzzle concerning the workings of the switch. |
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