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| 不同毒力钩端螺旋体引起THP-1细胞中细胞因子表达的研究 | |
| 引用本文： | 张彦,姜叙诚,郭晓奎,汤道强.不同毒力钩端螺旋体引起THP-1细胞中细胞因子表达的研究[J].微生物与感染,2011,6(2):101-107. |
| 作者姓名： | 张彦 姜叙诚 郭晓奎 汤道强 |
| 作者单位： | 1. 上海交通大学医学院病原生物学教研室,上海,200025 2. 上海交通大学医学院病理学教研室,上海,200025 3. 上海交通大学医学院附属仁济医院,上海,200127 |
| 基金项目： | 上海市科学技术委员会项目 |
| 摘 要： | 本文旨在通过观察不同毒力钩端螺旋体激活人单核巨噬细胞株THP-1中细胞因子信号途径的差异,探讨天然免疫在钩端螺旋体病发病机制中的作用.将3种不同毒力的钩端螺旋体--赖型有毒株Lai株、赖型减毒株IPAV株及非致病性Patoc型Patoc 1株与诱导后的细胞相互作用,在作用0、2、12、24、48 h 后收集标本,应用实... |
| 关 键 词： | 钩端螺旋体 THP-1 Toll样受体2 Toll样受体4 细胞因子 |
Cytokine responses induced by Leptospira strains with different virulence in THP-1 cells |
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| ZHANG Yan,JIANG Xu-Cheng,GUO Xiao-Kui,TANG Dao-Qiang.Cytokine responses induced by Leptospira strains with different virulence in THP-1 cells[J].Journal of Microbes and Infection,2011,6(2):101-107. | |
| Authors: | ZHANG Yan JIANG Xu-Cheng GUO Xiao-Kui TANG Dao-Qiang |
| Institution: | ZHANG Yan1,JIANG Xu-Cheng2,GUO Xiao-Kui1,TANG Dao-Qiang3 1.Department of Medical Microbiology and Parasitology,Institutes of Medical Sciences,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China,2.Department of Pathology,3.Renji Hospital,Shanghai 200127 |
| Abstract: | The purpose of this study is to observe the cytokine responses induced by Leptospira strains with different virulence in THP-1 cells and to evaluate the role of innate immunity in the pathogenesis of leptospirosis.THP-1 cells induced by phorbol myristoyl acetate(PMA) were incubated with three different Leptospira strains,the virulent Leptospira interrogans serovar Lai type strain Lai,the avirulent Leptospira interrogans serovar Lai type strain IPAV,and the nonpathogenic Leptospira biflexa serovar Patoc type... |
| Keywords: | THP-1 |
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