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| H9c2细胞对B组柯萨奇病毒3型重组株的易感性 | |
| 引用本文： | 林乐勋,赵文然,武帅钦,佟雷,王燕,张凤民,钟照华.H9c2细胞对B组柯萨奇病毒3型重组株的易感性[J].微生物与感染,2011,6(2):78-83. |
| 作者姓名： | 林乐勋 赵文然 武帅钦 佟雷 王燕 张凤民 钟照华 |
| 作者单位： | 1. 哈尔滨医科大学病原生物学实验教学中心,哈尔滨,150081;哈尔滨医科大学微生物学教研室,黑龙江省感染与免疫重点实验室,哈尔滨,150081 2. 哈尔滨医科大学细胞生物学教研室,哈尔滨,150081 3. 哈尔滨医科大学微生物学教研室,黑龙江省感染与免疫重点实验室,哈尔滨,150081 |
| 基金项目： | 国家自然科学基金，黑龙江省教育厅科技项目 |
| 摘 要： | H9c2细胞是来源于大鼠胚胎心脏组织的成肌细胞系,B组柯萨奇病毒(group B Coxsackievirus,CVB)是心肌炎和扩张型心肌病的主要病原.本研究观察了CVB3在H9c2细胞中的感染性,探讨H9c2细胞是否可用于CVB致心肌疾病的实验研究.用整合了增强型绿色荧光蛋白(EGFP)或海肾荧光素酶(RLuc)的... |
| 关 键 词： | H9c2细胞 B组柯萨奇病毒3型 心肌细胞 骨骼肌细胞 鼠 |
Infectivity of recombinant Coxsackievirus B3 in H9c2 cells |
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| LIN Le-Xun,ZHAO Wen-Ran,WU Shuai-Qin,TONG Lei,WANG Yan,ZHANG Feng-Min,ZHONG Zhao-Hua.Infectivity of recombinant Coxsackievirus B3 in H9c2 cells[J].Journal of Microbes and Infection,2011,6(2):78-83. | |
| Authors: | LIN Le-Xun ZHAO Wen-Ran WU Shuai-Qin TONG Lei WANG Yan ZHANG Feng-Min ZHONG Zhao-Hua |
| Institution: | LIN Le-Xun1,2,ZHAO Wen-Ran3,WU Shuai-Qin2,TONG Lei2,WANG Yan2,ZHANG Feng-Min2,ZHONG Zhao-Hua1,2 1.Experimental Teaching Center of Pathogen Biology,Harbin Medical University,Harbin 150081,China,2.Department of Microbiology and Key Laboratory of Heilongjiang Province for Infection and Immunity,3.Department of Cell Biology |
| Abstract: | H9c2 cells are a cardiac myoblast cell line derived from rat heart tissue.Group B Coxsackievirus(CVB) is the major pathogen of viral myocarditis and dilated cardiomyopathy.In this study,infectivity of CVB3 in H9c2 cells was observed to evaluate the value of H9c2 cells in the experimental study of CVB-induced myocardial diseases.H9c2 cells and cardiac and skeletal myocytes of BALB/c mouse and Sprague-Dawley(SD) rats were infected with two CVB3 variants integrated with enhanced green fluorescence protein(EGFP... |
| Keywords: | H9c2 cell Coxsackievirus B3 Cardiomyocyte Skeletal muscle cell Murine |
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