| 乙型肝炎病毒X蛋白对细胞凋亡的影响存在剂量依赖性 |
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| 引用本文： | 翟露露,刘晶,谢幼华.乙型肝炎病毒X蛋白对细胞凋亡的影响存在剂量依赖性[J].微生物与感染,2011,6(2):72-77. |
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| 作者姓名： | 翟露露 刘晶 谢幼华 |
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| 作者单位： | 复旦大学上海医学院教育部/卫生部医学分子病毒学重点实验室,上海,200032 |
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| 基金项目： | "十一五"国家科技重大专项 |
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| 摘 要： | 乙型肝炎病毒(HBV)X蛋白(HBx)与HBV相关肝细胞肝癌(HCC)的发生和发展密切相关.深入研究HBx在HCC形成中的作用将为探索HBV致癌机制提供重要依据.HBx是多功能蛋白,其对细胞凋亡的影响至今仍存在分歧.许多研究表明,HBx既有促进细胞凋亡又有抑制细胞凋亡的功能,但原因不清楚.本研究中,将表达HBx的质粒短...
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| 关 键 词： | 乙型肝炎病毒 乙型肝炎病毒X蛋白 核因子κB 凋亡 |
Dose-dependent modulation of cell apoptosis by hepatitis B virus X protein |
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| ZHAI Lu-Lu,LIU Jing,XIE You-Hua.Dose-dependent modulation of cell apoptosis by hepatitis B virus X protein[J].Journal of Microbes and Infection,2011,6(2):72-77. |
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| Authors: | ZHAI Lu-Lu LIU Jing XIE You-Hua |
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| Institution: | ZHAI Lu-Lu,LIU Jing,XIE You-Hua Key Laboratory of Medical Molecular Virology,Ministry of Education and Health,Shanghai Medical College,Fudan University,Shanghai 200032,China |
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| Abstract: | Hepatitis B virus X protein(HBx) plays a role in the development of hepatocellular carcinoma(HCC).Studies on the relationship between HBx and HCC development can provide an important basis for the mechanism of tumorigenesis of HBV.Among its various activities,HBx can regulate cell apoptosis and proliferation.However,whether HBx is anti-apoptotic or pro-apoptotic is still debatable.In this study,Huh7 and 293T cells were transiently transfected with HBx-expressing plasmid at different concentrations.The resul... |
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| Keywords: | Hepatitis B virus Hepatitis B virus X protein Nuclear factor κB Apoptosis |
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