Transfer of phospholipids between the endoplasmic reticulum and mitochondria in rat hepatocytes in vivo |
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Authors: | I Eggens C Valtersson G Dallner L Ernster |
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Institution: | 1. Department of Biochemistry, Arrhenius Laboratory, University of Stockholm, Stockholm, Sweden;2. Department of Pathology at Huddinge Hospital, Karolinska Institutet, Stockholm, Sweden |
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Abstract: | The transfer of phospholipids from the endoplasmic reticulum to the inner mitochondrial membrane was investigated by pulse labeling . With 3H]glycerol microsomal phosphatidylethanolamine and phosphatidylcholine were rapidly labeled during the first 30 min; while maximum incorporation into the inner mitochondrial membrane occurred only after about 5 hours. It appears that the transfer of these phospholipids between the two membrane compartments is a relatively slow process. |
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