A Sod2 null mutation confers severely reduced adult life span in Drosophila |
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| Authors: | Duttaroy Atanu Paul Anirban Kundu Mukta Belton Amy |
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| Affiliation: | Biology Department, Howard University, Washington, DC 20059, USA. aduttaroy@howard.edu |
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| Abstract: | A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2-/- progeny suffer neonatal lethality. Sodn283/+ heterozygotes are sensitive to oxidative stress induced by paraquat treatment. |
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