Identification of a nuclear protein matrix |
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| Authors: | R Berezney D S Coffey |
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| Affiliation: | Department of Pharmacology and Experimental Therapeutics The James Buchanan Brady Laboratory for Reproductive Biology, and The Oncology Center The Johns Hopkins University School of Medicine Baltimore, Maryland 21205 USA |
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| Abstract: | The structural framework of the rat liver nucleus has been identified and consists of a nuclear protein matrix. This matrix is 98.4% protein, 0.1% DNA, 1.2% RNA, and 0.5% phospholipid. The nuclear protein matrix is composed primarily of three acidic polypeptide fractions in the molecular weight range of 60–70,000 daltons. |
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