Transforming growth factor-beta blocks proliferation but not early mitogenic signaling events in T-lymphocytes |
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| Authors: | D R Morris C A Kuepfer L R Ellingsworth Y Ogawa P S Rabinovitch |
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| Affiliation: | Department of Biochemistry, University of Washington, Seattle 98195. |
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| Abstract: | Transforming growth factor-beta (TGF-beta) inhibits the proliferation of T-lymphocytes in response to activation with mitogenic lectin. The influence of TGF-beta on elevation of cytosolic Ca2+, induction of proliferation-associated mRNA species, and total cellular RNA content has been studied. The cells seem to exit G0 when activated in the presence of TGF-beta, but they arrest in mid-G1 phase. |
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