Rat LINE1: The origin and evolution of a family of long interspersed middle repetitive DNA elements |
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| Authors: | Marcelo Bento Soares Eric Schon Argiris Efstratiadis |
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| Affiliation: | (1) Department of Human Genetics and Development, Columbia University, 701 West 168th Street, 10032 New York, New York, USA;(2) Present address: Department of Neurology, College of Physicians and Surgeons, Columbia University, 630 West 168th Street, 10032 New York, New York, USA |
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| Abstract: | Summary We present approximately 7.0 kb of composite DNA sequence of a long interspersed middle repetitive element (LINE1) present in high copy number in the rat genome. The family of these repeats, which includes transcribing members, is the rat homologue of the mouse MIF-Bam-R and human Kpn I LINEs. Sequence alignments between speciments from these three species define the length of a putative unidentified open reading frame, and document extensive recombination events that, in conjunction with retroposition, have generated this large family of pseudogenes and pseudogene fragments. Comparative mapping of truncated elements indicates that a specific endonucleolytic activity might bei involved in illegitimate (nonhomologous) recombination events. Sequence divergence analyses provide insights into the origin and molecular evolution of these elements. |
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| Keywords: | Repetitive DNA Retroposon Pseudogene |
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