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MVA recombinants expressing the fusion and hemagglutinin genes of PPRV protects goats against virulent challenge |
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| Authors: | Dev Chandran Kolli Bhaktavatsala Reddy Shahana Pallichera Vijayan Parthasarthy Sugumar Gudavalli Sudha Rani Ponsekaran Santha Kumar Lingala Rajendra Villuppanoor Alwar Srinivasan |
| Institution: | (1) Indian Veterinary Research Institute, Izatanagar, 243 122 Bareilly, India;(2) Central Institute of Fisheries Technology, 682 029 Cochin, India;(3) Project Directorate on Foot-and-Mouth Disease, IVRI Campus Mukteswar-Kumaon, 263 138 Nainital, India;(4) Indian Veterinary Research Institute, Mukteswar Campus, 263 138 Nainital, India;(5) Animal Husbandry Commission, 234A, Krishi Bhavan, 110 001 New Delhi, India; |
| Abstract: | Peste des Petits Ruminants (PPR) is a highly contagious animal disease caused by the Peste des Petits Ruminants virus (PPRV) belonging to the genus morbillivirus and family Paramyxoviridae. The disease results in high morbidity and mortality in goats, sheep and in some small wild ruminants. The presence of large number of small ruminants reared in endemic areas makes PPR a notorious disease threatening the livelihood of poor farmers. Conventional vaccination using a live, attenuated vaccine gives adequate protection but cannot be used in case of eradication of the disease due to difficulty in differentiation of infected animals from the vaccinated ones. |
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