Influence of human B-casomorphin-7 on specific binding of 3H-spiperone to the 5-HT2-receptors of rat brain frontal cortex |
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| Authors: | Sokolov Oleg Yurievich Kost Natalya Vsevolodovna Zolotarev Yurii Aleksandrovich Ryukert Ekaterina Nikolaevna Zozulya Andrey Aleksandrovich |
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| Affiliation: | National Research Center for Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. sokolov@rcmh.msk.ru |
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| Abstract: | Using radio-receptor analysis, it has been demonstrated that human beta-casomorphin-7 (Tyr-Pro-Phe-Val-Glu-Pro-Ile) displaces 3H-spiperone from 5-HT2-receptors of rat brain frontal cortex. IC50 of human beta-casomorphin-7 was 8 microM. These data suggest that one of the mechanisms of neurotropic action of beta-casomorphin-7 is might be associated with its influence on the serotoninergic system. |
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