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Tumor-Associated Antigen Peptides as Anti-Metastatic Vaccines |
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| Authors: | Lea Eisenbach Ofer Mandelboim Erez Bar-Haim Lior Carmon Hernan Copcow Khaled El-Shami Adrian Paz Dan Popovic Ezra Vadai Esther Tzehoval Michael Feldman Mati Fridkin |
| Affiliation: | (1) Department of Immunology, The Weizmann Institute of Science, Rehovot, 76100, Israel;(2) Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot, 76100, Israel |
| Abstract: | Cytotoxic T-lymphocytes (CTLs) kill abnormal cells. CTLs recognize major histocompatibility complex class I molecules in complex with peptides derived from relevant antigens. The identification of tumor associated antigen peptides enabled the design of anti-tumor and anti-metastatic vaccines in a murine lung carcinoma. |
| Keywords: | immunotherapy MHC class I tumor metastases |
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