The effect of caffeine posttreatment of X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro |
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| Authors: | A T Natarajan G Obe F N Dulout |
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| Institution: | (1) Department of Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratories, University of Leiden, Wassenaarseweg 72, Leiden, The Netherlands;(2) Interuniversity Department of Radiation Pathology and Radiation Protection, J. A. Cohen Institute, Leiden, The Netherlands;(3) Genetics Institute, Free University, Arnimallee 5-7, D-1000 Berlin 33;(4) Instituto Multidisciplinario De Biologia Celular, La Plata, Argentina |
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| Abstract: | Summary The potentiating effect of caffeine on X-ray-induced chromosomal aberrations in human blood lymphocytes has been investigated, with special reference to cell cycle stages (G0 and G2). Both quantitative and qualitative differences in the yield of chromosomal aberrations were detected in caffeine-posttreated cells, depending on the cell stage irradiated. The studies on caffeine potentiating effects on X-irradiated G0 lymphocytes from normal adults, newborns, Down syndrome patients, and an ataxia telangiectasia patient pointed to interindividual variations in the response to caffeine potentiation among normal probands and a very profound effect in ataxia cells. |
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