Comparative changes with age of the fasting response in circulating ketone bodies, glucose and insulin and oral glucose tolerance test in the rat |
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| Authors: | J Codina M Vall E Herrera |
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| Institution: | 1. Research team, Pathophysiology and Epidemiology of Cerebro-Cardiovascular diseases (PEC2, EA 7460), University of Bourgogne Franche-Comté, UFR des Sciences de Santé, 7 boulevard Jeanne d’ Arc, 21079 DIJON, France;2. Cardiology Unit, Dijon University Hospital Center, Dijon, France;1. Department of Cardiology, Herlev-Gentofte University Hospital, Denmark;2. Faculty of Health and Medical Sciences, Copenhagen University, Denmark;3. Department of Cardiology, Odense University Hospital, Denmark;4. Faculty of Health Sciences, University of Southern Denmark, Denmark;5. Department of Endocrinology and Metabolism, Copenhagen University Hospital Rigshospitalet, Denmark;6. Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark;7. Department of Cardiology, Frederiksberg-Bispebjerg University Hospital, Denmark;8. Department of Cardiology, The Heart Center, Copenhagen University Hospital Rigshospitalet, Denmark;9. Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark;10. Steno Diabetes Center Copenhagen, Herlev, Denmark;11. Section of Biostatistics, Department of Public Health, University of Copenhagen, Denmark;12. Department of Clinical Physiology and Nuclear Medicine, Herlev Gentofte University Hospital, Copenhagen, Denmark;13. Steno Diabetes Center Odense, Odense University Hospital, Denmark;14. Department of Clinical Research, University of Southern Denmark, Odense, Denmark |
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| Abstract: | 1. Body weight loss in 48 hr fasted rats decreased with age. 2. Blood glucose and plasma RIA-insulin levels correlated negatively and positively respectively with body weight in fed rats. Fasting produced a greater fall in blood glucose and a smaller decrease in RIA-insulin in young than in old rats. 3. Blood ketone bodies correlated negatively with body weight after 48 hr fasting. 4. In oral glucose tolerance tests, blood glucose rose more in adult and old rats than in prepuberals when both fed and fasted. RIA-insulin levels rose more in prepuberals than in older rats when fed but not when fasted. 5. Changes in body composition and reduced insulin sensitivity with age are discussed. |
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