Inhibition of LPS-induced NO production by the oleogum resin of Commiphora wightii and its constituents |
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Authors: | Meselhy Meselhy R |
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Institution: | Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Kasr el-Aini Street, 11562 Cairo, Egypt. meselhyragab@yahoo.com |
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Abstract: | Three new (1-3) and five known compounds (4-8) were isolated from the oleogum resin of Commiphora wightii (Arnott.) Bhanol. Their structures were elucidated by spectroscopic and chemical methods. The MeOH extract and the EtOAc-sol. fraction were found to demonstrate significant inhibition of NO formation in lipopolysaccharide (LPS)-activated murine macrophages J774.1 in vitro (IC(50) values of 16.4 and 12.8 microg/ml, respectively). When compared with curcumin (IC(50) value of 12.3 microM), Z- and E-Guggulsterones (4 and 5, respectively) were the most potent inhibitors of NO production (IC(50) values of 1.1 and 3.3 microM, respectively), followed by myrrhanol A (7) and myrrhanone A (8) (IC(50) values of 21.1 and 42.3 microM, respectively). Guggulsterone-M (1) and its didehydro derivative (2) were weak inhibitors, while guggulsterols I (6) and Y (3) were inactive (IC(50) >500 microM). |
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Keywords: | Commiphora wightii Burseraceae Oleogum resin Steroids LPS-induced nitric oxide Murine macrophages J774 1 |
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