Synthesis of sulfur containing dihydro-pyrrolo derivatives and their biological evaluation as antioxidants |
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| Authors: | Dimitra Georgiou Vasilios Toutountzoglou Kenneth W Muir Dimitra Hadjipavlou-Litina Yiannis Elemes |
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| Affiliation: | Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. |
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| Abstract: | The 1,3-dipolar cycloaddition to N-phenylmaleimide of azomethine ylides, generated in situ from sulfanyl-substituted imines of glycine esters, yields 5H-dihydro-pyrrolo products with syn diastereoselectivity. The syn (major) and anti (minor) products were isolated chromatographically and fully characterized by spectroscopic methods and in two cases also by X-ray analysis. The diastereomeric cycloadducts were tested for their antioxidant activity with good results. |
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