Effect of proglumide, a cholecystokinin receptor antagonist, on caerulein-stimulated pancreatic enzyme secretion and pancreatic polypeptide release in the dog |
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Authors: | M Fried C Beglinger E Koehler I Whitehouse L Varga K Gyr |
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Affiliation: | 1. Division of Gastroenterology, University Hospital, Basel, Switzerland;2. University Hospital, Berne, Switzerland |
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Abstract: | In five conscious dogs we studied the effect of proglumide, a cholecystokinin (CCK) antagonist, on caerulein-stimulated pancreatic secretion and release of pancreatic polypeptide (PP). Graded doses of caerulein (15-240 ng/kg per h) were infused intravenously. Experiments were repeated with a fixed infusion of proglumide (40 mg/kg per h). Release of PP following increasing doses of caerulein was significantly inhibited by proglumide (P less than 0.01). However, proglumide did not significantly affect caerulein-stimulated pancreatic protein secretion. Proglumide might be useful in defining the physiological role of CCK. |
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Keywords: | proglumide pancreatic secretion pancreatic polypeptide dogs |
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