Dynamic aspects of presynaptic calcium currents mediating synaptic transmission |
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Authors: | Takahashi Tomoyuki |
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Institution: | Department of Neurophysiology, University of Tokyo Graduate School of Medicine, Tokyo 113-0033, Japan. ttakahas-tky@umin.ac.jp |
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Abstract: | Ca2+ entry through voltage-gated Ca2+ channels (VGCC) triggers transmitter release. Direct recording of Ca2+ currents from the calyx of Held nerve terminal revealed that presynaptic VGCCs undergo various modulations via presynaptic G protein-coupled receptors (GPCRs), Ca2+-binding proteins and a developmental switch of their alpha1 subunits. Dynamic changes of presynaptic VGCCs alter synaptic efficacy, thereby contributing to a variety of modulations of the CNS function. |
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