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Thermophilic cytochrome P450 enzymes
Authors:Nishida Clinton R  Ortiz de Montellano Paul R
Institution:Department of Pharmaceutical Chemistry, University of California, 600 16th Street, San Francisco, CA 94143-2280, USA.
Abstract:Thermophilic cytochrome P450 enzymes are of potential interest from structural, mechanistic, and biotechnological points of view. The structures and properties of two such enzymes, CYP119 and CYP175A1, have been investigated and provide the foundation for future work on thermophilic P450 enzymes.
Keywords:Thermophilic hemoprotein  P450 structure  P450 mechanism  P450 topological probes  Hyperbaric stability  Heme modification
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