Immunohistochemical studies in diagnosis of the uncommon cases of tumours of the central nervous system

There is a growing evidence that tumoursof the central nervous system (CNS) exhibit some immunophenotypic aberrations pointing to the multipotential cell differentiation. However, the immunohistochemistry remains still very helpful in differential diagnosis and nosologic classification of the CNS neoplasms. The purpose of this paper is to present the immunomorphological pattern of some rare neoplasms of neuroepithelial origin that over last years were recognised and classified as new clinico-pathological entities. Histological and immuniohistochemical features of three cases including pleomorphic xanthoastrocytoma, chordoid glioma and central neurocytoma are reported with special references to immunohistochemical differentiation of these neoplasmswith other tumours of similar morphology but different histogenesis.