Synthesis and antidiabetic activity of morpholinothiazolyl-2,4-thiazolidindione derivatives |
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Authors: | Ezer Melis Yıldırım Leyla Tatar Bayro Ornela Verspohl Eugen J Dundar Oya Bozdag |
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Affiliation: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Tandogan, Ankara, Turkey. |
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Abstract: | We report the synthesis and the in vitro insulin releasing and glucose uptake activity of the morpholino thiazolyl-2,4-thiazolidinediones (1-15). Compounds 5, 11-15 (at lower concentration; 0.001?mg/ml) were able to increase insulin release in the presence of 5.6 mmol/l glucose. The compounds, except derivative 3 show an increase of glucose uptake. Various compounds are interesting potential antidiabetic leads showing pancreatic and extrapancreatic effects. |
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