Extraepithelial cells expressing distinct olfactory receptors are associated with axons of sensory cells with the same receptor type

During critical phases of mouse development, axons from olfactory sensory neurons grow out of the nasal neuroepithelium and navigate through the connective mesenchyme tissue towards their targets in the developing telencephalic vesicle. Between embryonic days E11 and E16, populations of cells are located in the mesenchyme which express distinct olfactory receptor genes along with the olfactory marker protein (OMP); thus they express markers characteristic for mature olfactory sensory neurons. These extraepithelial cells are positioned along the axon tracts, and each population expressing a given receptor gene is specifically associated with the axons of those olfactory sensory neurons with the same receptor type. The data suggest that they either might be guide posts for the outgrowing axons or migrate along the axons into the brain.