Expression of PGK-A in the Australian brush-tailed possum,Trichosurus vulpecula (Kerr), consistent with paternal X inactivation |
| |
Authors: | J L VandeBerg J E Thiel R M Hope D W Cooper |
| |
Institution: | (1) School of Biological Sciences, Macquarie University, 2113 North Ryde, New South Wales, Australia;(2) Present address: Laboratory of Genetics, University of Wisconsin-Madison, 53706 Madison, Wisconsin;(3) Science Department, Murray Park College of Advanced Education, 5072 Magill, South Australia, Australia;(4) Department of Genetics, University of Adelaide, 5001 Adelaide, South Australia, Australia |
| |
Abstract: | An extensive survey of erythrocytes of marsupials other than kangaroos for electrophoretic variation in X-linked enzymes revealed two rare PGK-A phenotypes in the phalangerid Trichosurus vulpecula and one in Trichosurus caninus. Four putatively heterozygous females expressed only the variant allelic isozyme in some tissues but expressed a trace of the normal isozyme in others. A putatively hemizygous male expressed only the variant isozyme in all tissues. The phenotypic patterns were consistent with those observed in kangaroos known to exhibit partial or complete paternal X inactivation in cells of females. Two of the T. vulpecula were a mother and her female pouch young, further suggesting that paternal X inactivation occurs in T. vulpecula. This peculiar mechanism of dosage compensation may not be restricted to kangaroos.This work was supported by grants to D. W. C. from the Australian Research Grants Committee and Macquarie University, J. L. V. was the recipient of a Fulbright-Hays Award from the Australian-American Educational Foundation and a postgraduate fellowship from General Motors-Holden. |
| |
Keywords: | marsupial phosphoglycerate kinase (PGK) isozymes dosage compensation paternal X inactivation |
本文献已被 SpringerLink 等数据库收录! |
|