主要干性基因与衰老相关基因表达水平的相互拮抗关系

目前广泛地利用传统的体细胞衰老理论和方法对成体干细胞衰老进行研究,忽视了成体干细胞特有的自我更新功能和相应的干性基因的作用.干性基因的下调可能是导致间充质干细胞衰老的主要原因.通过查阅相关资料发现主要干性基因与衰老相关基因表达水平的相互拮抗关系,这体现在以下4个方面:a.干细胞衰老伴随着干性基因的下调;b.干性基因表达抑制细胞的衰老;c.干性基因抑制衰老相关基因的表达;d.抑制衰老相关基因促进干性基因的表达.干性基因与衰老相关基因的表达水平存在相互拮抗关系,这为成体干细胞衰老可能源于成体干细胞的干性降低的观点提供了坚实的分子基础.

The Expression Levels of The Stem Genes and Aging-related Genes Are Associated With Mutual Antagonism

The aging of adult stem cells has been researched by the traditional theories and methods of the aging of somatic cells and the unique role of the self-renew and the stem genes of adult stem cells has been ignored by now in the aging of adult stem cells. The down-regulation of stem genes may be the major cause of the aging of stem cells. By analysis of the relevant information, we found that the expression levels of the stem genes and aging-related genes are associated with mutual antagonism which can be reflected in the following four aspects: The aging of stem cells is accompanied by down-regulation of the stem genes; The aging of cells is inhibited by the expression of the stem genes; The stem genes inhibits the expression of aging-related genes; The knockdown of an aging-related gene enhances the expression of the stem genes. The conclusion in this review that the expression levels of the stem genes and aging-related genes are associated with mutual antagonism provides a solid molecular basis of the viewpoint that the aging of adult stem cells may originate from the decline of stemness.