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The role of heterogeneity of tumour cell populations in biological activity and sensitivity to chemotherapeutics. |
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| Authors: | L Holczinger G Túri E Oláh F Gál |
| Abstract: | The biological activity of a rat ascites leukaemia subline isolated by isopycnic centrifugation was compared to that of the original tumour both in vivo and in vitro. The subline had different marker chromosomes, a longer cell cycle time and decreased sensitivity to vinblastine as compared to the original tumour. |
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