Establishment of a T lymphoid cell line producing a retrovirus of HTLV-I type, from peripheral blood of a patient with tropical spastic paraparesis |
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| Authors: | A Gessain F Saal D Vilette J Lasneret M L Giron F Sigaux O Gout R Emanoil-Ravier G de Thé J Periés |
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| Affiliation: | Institut de Recherches sur les Maladies du Sang, Laboratoire de Virologie des Leucémies, L.O.I.-C.N.R.S., H?pital Saint-Louis, Paris. |
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| Abstract: | HTLV-I, the causative agent of Adult T cell Leukemia, has recently been found to be associated with chronic neuromyelopathies common in tropical areas and in Japan. We report here the establishment of a lymphoid T cell line from peripheral blood lymphocytes of a patient with Tropical Spastic Paraparesis. This cell line produces a retrovirus whose morphologic, antigenic and genetic characteristics show no detectable difference from the leukemogenic prototype of HTLV-I. |
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