Decreased activities of S-adenosylmethionine synthetase isozymes in hereditary hepatitis in Long-Evans rats |
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| Authors: | K Shimizu M Abe S Yokoyama H Takahashi N Sawada M Mori K Tsukada |
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| Institution: | Department of Pathological Biochemistry, Tokyo Medical and Dental University, Japan. |
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| Abstract: | Isozyme patterns of S-adenosylmethionine synthetase have been measured with or without dimethylsulfoxide in liver of LEC rat hereditary hepatitis. The activities of the alpha- and beta-forms are decreased with age after birth, and decreased to a half level of 36 weeks after birth. Concentration of S-adenosylmethionine in the liver is almost a half level of control rat. However, the activity of glycine- and tRNA-methyltransferases in the liver shows no significant change. |
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