Lectin binding in the diabetic rat kidney |
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Authors: | T. H. Rosenquist and T. Huff |
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Affiliation: | (1) Department of Anatomy, Medical College of Georgia, 30912 Augusta, Georgia, USA;(2) Department of Medicine, 30912 Augusta, Georgia, USA |
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Abstract: | Summary In this study metal-conjugated concanavalin A (Con A) andBandieraea simplicifolia isolectin II (BSA II) have been applied to sections from kidneys of controls rats and rats which had untreated diabetes for 70 days or for 200 days. Lectin binding was measured by atomic absorption spectrophotometric analysis of ferritin-iron or hemocyanin-copper.Con A binding increased significantly with diabetes; was totally blocked by alpha-D-mannoside; was not inhibited by fructose lysine; and was enhanced by NaHB4 preincubation. BSA II binding also increased significantly with diabetes. |
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