Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events. |
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Authors: | B E Clurman and W S Hayward |
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Affiliation: | Sloan-Kettering Institute for Cancer Research, New York, New York 10021. |
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Abstract: | We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression. |
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