Location and the primary structure around the disulfide bonds in cholera toxin. |
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Authors: | E Mendez C Y Lai A Wodnar-Filipowicz |
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Affiliation: | Roche Institute of Molecular Biology Nutley, New Jersey 07110 USA |
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Abstract: | The sequence of the four tryptic peptides containing cysteine from cholera toxin has been determined. The cysteine residue in peptide A2, forms a disulfide bridge with the cysteine in the A1 chain located near the NH2-terminus. The region around the latter cysteine residue is characterized by a high content of proline. One of the cysteine residues that form the intrachain disulfide bond in subunit B has been located at position 9 in this subunit. |
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