The channel function of the hydrophobic fragment of Ca ATPase in the sarcoplasmic reticulum of rabbit skeletal muscles in the early period after x-ray radiation exposure |
| |
Authors: | V M Vo?tski? A N Fedorov N E Kucherenko M D Kurski? S V Khizhniak |
| |
Abstract: | At early times (1 and 24 h) following local single exposure of rabbit hindlimbs to 0.21 C/kg X-radiation Ca ATPase was isolated from sarcoplasmic reticulum of skeletal muscles and inserted in liposomes the treatment of which with trypsin resulted in the formation of proteoliposomes with a Ca ATPase hydrophobic fragment (Mr 45-50 kDa). It was shown that X-radiation increased the permeability of univalent and bivalent cations through a channel formed by the hydrophobic fragment of Ca ATPase and diminished ion selectivity of this channel. |
| |
Keywords: | |
|