No simple dependence between protein evolution rate and the number of protein-protein interactions: only the most prolific interactors tend to evolve slowly |
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Authors: | I?King?Jordan Yuri?I?Wolf Email author" target="_blank">Eugene?V?KooninEmail author |
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Institution: | (1) National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD, 20894 |
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Abstract: | Background It has been suggested that rates of protein evolution are influenced, to a great extent, by the proportion of amino acid residues
that are directly involved in protein function. In agreement with this hypothesis, recent work has shown a negative correlation
between evolutionary rates and the number of protein-protein interactions. However, the extent to which the number of protein-protein
interactions influences evolutionary rates remains unclear. Here, we address this question at several different levels of
evolutionary relatedness. |
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Keywords: | |
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