Presence of norepinephrine and other biogenic amines in stonefish venom |
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| Authors: | Pascale Garnier Jeanne-Marie Grosclaude Françoise Goudey-Perrière Vincent Gervat Philippe Gayral Christian Jacquot Claude Perrière |
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| Institution: | aLaboratoire de Biologie et Contrôle des Organismes Parasites, Université de Paris-Sud, 92296 Châtenay-Malabry Cedex, France;bLaboratoire de Pharmacologie, Faculté de Pharmacie, Université de Paris-Sud, 92296 Châtenay-Malabry Cedex, France;cLaboratoire de Chimie Structurale Organique et Biologique, EP 103, Université Pierre et Marie Curie, 4 Place Jussieu, 75252 Paris Cedex 05, France |
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| Abstract: | Although fish venoms exert a cardiovascular effect, the presence of adrenergic substances was not previously demonstrated. Chromatographic analysis with electrochemical detection showed the presence of substances co-migrating with norepinephrine, dopamine and tryptophan. Serotonin, which was thought to be implicated in the intense pain following fish envenomation, was not detected. Norepinephrine was identified as a component of the stonefish Synanceia verrucosa venom by gas chromatography-mass spectrometry. |
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| Keywords: | Norepinephrine Dopamine Tryptophan |
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