Combined effect of gender and caloric restriction on liver proteomic expression profile |
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| Authors: | Valle Adamo Silvestri Elena Moreno Maria Chambery Angela Oliver Jordi Roca Pilar Goglia Fernando |
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| Affiliation: | Grup de Metabolisme Energetic i Nutricio, Departament de Biologia Fonamental i Ciencies de la Salut, Institut Universitari d'Investigacio en Ciencies de la Salut, Universitat de les Illes Balears, Palma de Mallorca, Spain. vdbsavg4@uib.es |
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| Abstract: | We analyzed the combined effect of gender and CR on protein expression profile in liver. We identified 27 differentially expressed proteins involved in several cellular functions such as substrate metabolism, antioxidant systems, stress response, iron homeostasis and cardiovascular protection. This study reveals new cellular pathways liable to be similarly regulated in females and calorie restricted rats and which could be related with the greater longevity in these animals. |
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