Plasmodium cynomolgi: influence of x-irradiation and sporozoite dilution on relapse patterns in infected rhesus monkeys |
| |
| Authors: | M Warren G Powers P C Garnham T Shiroishi |
| |
| Affiliation: | 1. National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Parasitic Diseases, Bethesda, Maryland 20014, U.S.A.;2. University of London, School of Hygiene and Tropical Medicine, England |
| |
| Abstract: | It has been possible to demonstrate a direct relationship between number of sporozoites in an inoculum and the number of subsequent relapses in experimental infections with Plasmodium cynomolgi. The reduction in Sporozoite numbers was accomplished through the use of two techniques; (1) X-irradiation and (2) volumetric dilution. The authors conclude that these observations tend to support a concept of latency as an explanation for relapse and delayed patency in malaria. It is difficult to reconcile these results with the generally accepted concept of a continuous cycle of liver schizogony in relapsing malarias. |
| |
| Keywords: | Malaria Sporozoites Relapse X-irradiation Sporozoite dilution Chloroquine Chemotherapy Rhesus monkeys Address request for reprints to: Laboratory of Parasitic Diseases, NIAID, National Institutes of Health, Bethesda, Md. 20014. |
| 本文献已被 ScienceDirect 等数据库收录！ |
