Suppression by ethanol of acetate and hexanoate oxidation studied by nonrecirculating liver perfusion |
| |
Authors: | K O Lindros |
| |
Affiliation: | Instituto de Ingeniería, Universidad Nacional Autónoma de México (UNAM), Coyoacán, Ciudad de México, C.P. 04510, Mexico;Professor of Biomedical Sciences, Emeritus Cummings School of Veterinary Medicine Tufts University |
| |
Abstract: | The relationship between the effect of ethanol on the redox state and the tricarboxylic acid cycle has been studied by perfusion of hemoglobin-free medium through the liver without recirculation. The production of 14CO2 from 1-14C-acetate was suppressed 63 % by ethanol and that from 1-14C-hexanoate by 54 % in normal livers. These suppressions were much weaker in livers from hyperthyroid rats and stronger in those from hypothyroid rats. Conditions where the ethanol-induced elevation of the lactate/pyruvate ratio was decreased led to less suppression of substrate oxidation by ethanol. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|