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Platelet calcium pump activity in essential hypertensives and their first-degree relatives |
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| Authors: | S. Gulati M. Khullar B. K. Sharma N. K. Ganguly |
| Affiliation: | (1) Departments of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, 160 012 Chandigarh, India;(2) Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, 160 012 Chandigarh, India;(3) Department of Experimental Medicine, Postgraduate Institute of Medical Education and Research, 160 012 Chandigarh, India |
| Abstract: | Intracellular free Ca2+ concentration has been shown to be elevated in platelets of patients with essential hypertension. This study was designed to characterize Ca2+-pump activity of the platelet membranes (surface and intracellular) in these patients. A double-blind study was carried out. Untreated and treated (on R-blockers) essential hypertensives were studied in comparison with normotensive control subjects. First degree blood relatives of essential hypertensives were also studied. The Ca2+-activation kinetics of the enzyme showed a significant decrease in the Vmax. (for the plasma- and intracellular membranes) and Km (for the intracellular membranes) in the essential hypertensive patients. Increased platelet membrane cholesterol content was observed in these patients. Lowered Ca2+-efflux by Ca2+-ATPase may lead to elevated intracellular free Ca2+-levels in platelets of essential hypertensives. A lowered Ca2+-ATPase activity may emerge as a marker for essential hypertension. |
| Keywords: | platelet plasma membranes intracellular membranes essential hypertension Ca2+-ATPase |
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