| 酒精依赖相关基因的遗传多态性 |
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| 引用本文： | 贺艮峰,钟树荣,景强.酒精依赖相关基因的遗传多态性[J].遗传,2008,30(4):413-418. |
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| 作者姓名： | 贺艮峰 钟树荣 景强 |
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| 作者单位： | 昆明医学院法医学院, 昆明 650031 |
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| 摘 要： | 酒精依赖综合征受到复杂的生理、心理、个体遗传及环境等诸多因素的影响。有关研究已经证实了某些候选基因和酒精依赖密切相关。文章主要对与酒精依赖相关的酒精代谢关键酶(乙醇脱氢酶和乙醛脱氢酶以及细胞色素P450 2E1)基因以及调节神经递质作用的酶和受体(儿茶酚氧位甲基转移酶, 多巴胺受体D2、D4, μ阿片受体)基因遗传多态性研究作一综述。
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| 关 键 词： | 多态性 基因 遗传 酒精依赖 |
| 收稿时间： | 2007-10-04 |
| 修稿时间： | 2007年10月4日 |
Genetic polymorphism for genes of alcohol dependence |
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| HE Gen-Feng,ZHONG Shu-Rong,JING Qiang.Genetic polymorphism for genes of alcohol dependence[J].Hereditas,2008,30(4):413-418. |
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| Authors: | HE Gen-Feng ZHONG Shu-Rong JING Qiang |
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| Institution: | Department of Forensic Medicine, Kunming Medical College, Kunming 650031, China |
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| Abstract: | Alcohol dependence is a complex disorder which is influenced by physiological, psychological, environmental factors, individual inheritance and so on. Several candidate genes associated with alcohol dependence risk have been identified. The review focuses on several related genes that control alcohol metabolism such as alcohol dehydrogenase, aldehyde dehydrogenase, cytochrome P450 2E1 and regulate neurotransmission such as catechol-O-methyltransferase, dopamine receptors D2 and D4, and mu opioid receptor. |
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