Trace element status (Se, Cu, Zn) in healthy portuguese subjects of Lisbon population |
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Authors: | P A Lopes M C Santos L Vicente M O Rodrigues M L Pavao J Nève A M Viegas-Crespo |
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Institution: | Centro de Biologia Ambiental and Departamento de Biologia Animal, Faculdade de Ciências de Lisboa, 1749-016 Lisboa, Portugal. |
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Abstract: | Serum levels of selenium, copper, and zinc were systematically determined in healthy subjects of the Lisbon population. The
sample consisted of 183 blood donors of both genders who were divided into two age groups: 20–44 and 45–70 yr of age; relationships
with gender, age, the lipid profile, and tobacco consumption were investigated. In the female group, the intake of oral contraceptives
and pregnancy were considered for the youngest women, and hormonal replacement therapy (HRT) was taken into account for the
oldest ones. Serum concentrations of these elements were in the same range as those found for populations of other European
countries. Differences between genders were observed for the three elements studied, with serum selenium and zinc concentrations
higher in men and copper levels higher in women. Age-dependent differences were found for selenium: The oldest subjects (regardless
gender) presented the highest concentrations of selenium in serum as further demonstrated by the positive correlation with
age. In both pregnant and contraceptive-using women, copper was greatly increased, confirming the influence of estrogen status
and/or oral contraceptive intake on increased serum copper levels. However, in postmenopausal women, HRT did not significantly
affect serum copper levels. Selenium, copper, and zinc status were not different between normolipidemic and hyperlipidemic
subjects for the same gender and age range, but selenium levels tended to increase with hyperlipidemia when considering the
whole group of subjects. With respect to the lifestyle, higher serum zinc levels were found in tobacco-consuming men. Albumin
serum levels were similar for all considered subgroups, except for the pregnant women, for whom a decrease in this parameter
was observed. The present study allowed one to obtain reference values for this healthy group of population, which will serve
for a comparative study with groups having pathological conditions, such as cardiovascular disease. |
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Keywords: | Trace elements selenium copper zinc albumin lipid profile hormonal status smoking habits |
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