Possibility of membrane modification as a mechanism of antimony resistance in Leishmania donovani |
| |
| Authors: | Kothari Hema Kumar Pranav Sundar Shyam Singh Neeloo |
| |
| Affiliation: | Drug Target Discovery and Development Division, Central Drug Research Institute, Lucknow, India. |
| |
| Abstract: | Resistance to antimonials has become a clinical threat in the treatment of visceral leishmaniasis (VL). Unravelling the resistance mechanism needs attention to circumvent the problem of drug resistance. In one of the resistant isolates, we earlier identified a gene (PG1) implicated in antimony resistance whose localization in the present study was confirmed on the pellicular plasma membrane of the parasite thereby indicating towards membrane modification as a mechanism of resistance in this resistant isolate. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
