Decreased expression of MMP-9 in CD8+ cells in placenta with severe preeclampsia |
| |
| Authors: | M Orlovic V Tomic K Vukojevic I Hudic V Mandic I Azinovic |
| |
| Institution: | 1. Department of Gynecology, University Hospital in Mostar;2. Faculty of Health Studies, University of Mostar;3. Laboratory of Morphology, Department of Histology and Embryology, School of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina;4. Laboratory for Early Human Development, Department of Anatomy, Histology and Embryology, School of Medicine, University of Split, Split, Croatia;5. Clinic of Gynecology and Obstetrics, University Clinical Center, Tuzla |
| |
| Abstract: | We compared the number of CD4-positive (CD4+) and CD8-positive (CD8+) cells in severe and non-severe preeclampsia (PE), and in normal pregnancy. We also evaluated the expression of matrix metalloproteinase 9 (MMP-9) in CD4+ and CD8+ cells. Immunohistochemistry for CD4+ and CD8+ was performed on the decidua basalis of 15 severe and 13 non-severe PE women and compared to decidual tissue of 19 normal pregnancies (control group). Co-expression of MMP-9 with CD8+ and CD4+ cells was determined by double immunofluorescence staining. The median number of CD8+ cells/mm2 was significantly lower for the severe PE group than for the normal pregnancy group, as was the number of CD4+ cells and MMP-9+CD8+ cells. No statistical difference was found between the non-severe PE group and the normal pregnancy group. The significant decrease of CD4+, CD8+ and MMP-9+CD8+ cells at the fetal-maternal interface only in the severe PE group suggests that immunological disorders play a role in the pathophysiology of severe PE. |
| |
| Keywords: | CD4 CD8 decidua basalis immunohistochemistry MMP-9 placenta preeclampsia |
|
|
