A histopathological and stereological study of liver damage in female rats caused by mercury vapor |
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| Authors: | A Yahyazedeh BZ Altunkaynak N Akgül HM Akgül |
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| Institution: | 1. Department of Histology and Embryology, Faculty of Medicine, Ondokuz May?s University, Samsunberrinzuhal@gmail.com;3. Department of Histology and Embryology, Faculty of Medicine, Ondokuz May?s University, Samsun;4. Departments of Restorative Dentistry;5. Oral Diagnosis and Radiology, Faculty of Dentistry, Atatürk University, Erzurum, Turkey |
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| Abstract: | We examined the possible effects of elemental mercury vapor on the liver of the female rats. We divided the animals into an untreated control group and an experimental group that was exposed to mercury vapor for 45 days. Liver samples were obtained for histological and stereological analysis. The total liver, parenchyma and sinusoid volumes were increased significantly in the mercury vapor treated group compared to controls. Also, the mean density, total number and mean nuclear diameter of hepatocytes, except for binucleated hepatocytes, was decreased in the experimental group compared to controls. Light and electron microscopy revealed alterations of liver structure of the experimental animals compared to controls. |
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| Keywords: | electron microscopy histology liver mercury vapor rat stereology toxicity |
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