Synthesis and antitumor evaluation of benzoylphenylurea analogs |
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| Authors: | Gurulingappa Hallur Amador Maria L Zhao Ming Rudek Michelle A Hidalgo Manuel Khan Saeed R |
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| Institution: | The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21231, USA. |
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| Abstract: | Novel series of benzoylphenylurea analogs 7-10 were prepared and evaluated for in vitro cytotoxic activity against a panel of eight different human cancer cell lines. A very interesting inhibition profile against BxPC3, Mia-Paca, and Hep2 cells with compound 10 has been observed. Compounds 8 and 9 showed the significant cytotoxicity in Hep2 cells. All cell lines were resistant to compound 7. |
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